This CCNMD is comprised of 5 projects designed to collaborate around the investigation of one central hypothesis:
Project 1 - Molecular abnormalities in schizophrenia in distinct subsets of cortical GABA neurons thought to generate oscillatory activity
Project 2 - Integrated computational, electrophysiological and anatomical approaches to determine the relationship between cell type-specific cortical GABA neurotransmission and oscillations in vitro
Project 3 - The role of GABA neurotransmission in cortical oscillations elicited by tasks that tap in non-human primates the same information processing domains that are altered in schizophrenia
Project 4 - Specific types of information processing disturbances in schizophrenia that are linked to altered activation of, and impaired network oscillations in, certain cortical regions
Project 5- The development of new PET imaging tools for studying the function of human cortical GABA neurons in vivo
All five projects and their coordination are supported by the Conte Center Administrative, Clinical Services and Diagnostics, and Statistics and Data Management teams.
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Corrie Long